Recently, topics related to lupus erythematosus have frequently appeared on Weibo hot searches, attracting the attention of many netizens. So what exactly is lupus erythematosus? What symptoms should I be wary of? Can it cure?
It is more common in women of childbearing age. You should be careful when these symptoms occur.
Public information shows that Lupus erythematosus is a general term for a type of chronic, recurring autoimmune disease, which is common in women of childbearing age. The most characteristic symptom of lupus erythematosus is the butterfly-shaped erythematosus on the cheek. The name "lupus" was precisely because in the past, people thought that the facial erythema of the disease was caused by a wolf bite.
There are many types of lupus erythematosus, among which systemic lupus erythematosus (SLE) is a typical autoimmune connective tissue disease . It is more common in women in the childbearing period between 15 and 40 years old. It also occurs in children , accounting for about all 20% of SLE cases. In recent years, the incidence of systemic lupus erythematosus in children has increased significantly. And compared with adults, children with SLE have a more acute onset, more severe illness, and a longer course of disease than adults..
Systemic lupus erythematosus (SLE) is one of the three most difficult diseases in the world. Its distinctive feature is that it is a chronic disease that is difficult to cure, requires long-term treatment, and suffers long-term suffering from patients. It is also known as the "immortal cancer".
Systemic lupus erythematosus can involve multiple organs , and symptoms are diverse and complex .
The following are related symptoms: :
Systemic symptoms: Fever (mainly low and moderate fever), fatigue, tiredness, anorexia, weight loss, etc.
Skin and mucous membrane symptoms : including butterfly-shaped erythema, mucosal ulcers, hair loss and alopecia areata, as well as red and painful nodules on the fingers and palms, periungual erythema and skin ulcers, ischemic necrosis of the fingertips, etc. Among them, erythema-like rash occurs in about half of the patients, and is less likely to occur in early-stage patients.
Muscle and joint symptoms: has joint pain and limited activity, myalgia and muscle weakness.
Neuropsychiatric symptoms: such as headache, delirium, epilepsy, delusions or hallucinations, coma, peripheral neuritis and other manifestations.
Kidney involvement symptoms: may have symptoms such as hematuria, elevated blood pressure, general edema, loss of appetite, morning nausea and vomiting, skin itching, and bleeding tendencies.
Symptoms of lung involvement: can manifest as a variety of clinical symptoms such as alveolitis, interstitial pneumonia, bronchiolitis, and alveolar hemorrhage.
Symptoms of blood system involvement: include symptoms of anemia, leukocyte and thrombocytopenia, and some patients may also have mild or moderate lymphadenopathy. Specific symptoms include pale skin and mucous membranes, fatigue, dizziness, decreased appetite, and bleeding tendencies.
Symptoms of cardiovascular system involvement: can show symptoms of pericarditis, endocarditis, myocardial damage, and coronary artery damage. Specific symptoms include precordial discomfort, shortness of breath, palpitations, cardiac insufficiency, etc.
Digestive system involvement symptoms: In addition to non-specific symptoms such as loss of appetite, nausea, vomiting, and abdominal pain, may also cause lesions in the intestines, pancreas, liver and other organs.
Symptoms of lacrimal gland and salivary gland involvement: symptoms of dry mouth and eyes may occur.
Eye involvement symptoms: mainly reduces vision and even causes blindness.
Symptoms of serositis: manifests as pleural effusion, pericardial effusion, and peritoneal effusion. Specific symptoms include chest tightness, shortness of breath, difficulty breathing, palpitations, abdominal distension, and loss of appetite.
There are approximately 1000,000 SLE patients in my country, and the incidence rate ranks second in the world
The "2020 China Systemic Lupus Erythematosus Diagnosis and Treatment Guidelines" (hereinafter referred to as the "Diagnosis and Treatment Guidelines") formulated by the Rheumatology Branch of the Chinese Medical Association shows that my country's SLE The incidence rate is about 30～70/100,000. The "China Systemic Lupus Erythematosus Development Report 2020" (hereinafter referred to as the "Report") released by the National Clinical Research Center for Skin and Immune Diseases pointed out that it is estimated that there are approximately 1 million SLE patients in my country, and the incidence rate ranks highest in the world. second. According to the "Report", although the 10-year survival rate of SLE patients in my country has risen to the current 89%, the survival rate after 25-30 years shows a cliff-like decline, only 30%.
Zeng Xiaofeng, director of the National Clinical Research Center for Skin and Immune Diseases and director of the Rheumatology and Immunology Department of Peking Union Medical College Hospital, pointed out in his interpretation of the "Report" that we have now achieved a 10-year survival rate for SLE patients that is comparable to that of developed countries. Target. However, as the course of the disease prolongs, almost all SLE patients will experience varying degrees of organ involvement, accompanied by the gradual accumulation of irreversible damage to the organs, eventually leading to multiple organ failure and death of the patient.
is called the "immortal cancer" There is no cure yet
Current research believes that systemic lupus erythematosus SLE is caused by genetic factors, environmental factors (such as ultraviolet rays, viral infections, drugs, biological products, blood products, etc.), sex hormone abnormalities, pregnancy , injuries caused by childbirth, social psychology and other factors combined.
To date, lupus erythematosus is incurable and cannot be cured. The goals of treatment are to improve symptoms, control the disease, ensure long-term survival, prevent organ damage, reduce disease activity and adverse drug reactions as much as possible, improve patients' quality of life and guide patients to manage the disease.
Normally, systemic lupus erythematosus is mainly treated with glucocorticoids combined with immunosuppressants. However, long-term use of hormones can cause many side effects, such as obesity and hairiness. Many patients stop taking the medicine at will because they cannot accept it. Some patients feel that their condition has improved and stop taking the medicine on their own initiative. As a result, the disease relapses and they use higher doses of hormones. Therefore, in order to achieve efficient treatment effect , patients should strictly follow the doctor's instructions when seeing a doctor.
Lupus erythematosus is a common chronic disease in our country, is just a disease that is difficult to cure, is not an incurable disease. With the continuous improvement of the diagnosis and treatment of SLE, the survival rate of SLE patients has increased significantly. SLE has transformed from an acute and highly fatal disease to a chronic and controllable disease.
Li Mengtao, director of the Office of the National Clinical Research Center for Skin and Immune Diseases and deputy director of the Department of Rheumatology and Immunology of Peking Union Medical College Hospital, once introduced at the "Report" interpretation meeting that At present, basic, clinical, and translational research on rheumatic immune diseases at home and abroad have made great achievements. Fruitful results have been achieved. The advent of targeted drugs such as biologics has made it possible for patients with systemic lupus erythematosus to reduce their hormone dosage and achieve organ protection. Note : The information in this article comes from the Internet
This article is written by Medical Toutiao
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