On July 17, local time in the United States,
"Martial Arts Queen" Ms. Zheng Peipei passed away in San Francisco, USA at the age of 78.
Previously reported:
Actor Zheng Peipei, who played many classic roles, passed away! Cao Kefan: She speaks old-fashioned Shanghainese and is very kind.
Zheng Peipei was diagnosed with a rare disease before her death and chose to donate her brain for research; her daughter mourns: her mother is one of the most selfless people
Zheng Peipei suffered from a rare disease
and will donate her brain for research
According to media reports , in 2019, Zheng Peipei was diagnosed with neurodegenerative atypical parkinsonism syndrome - informally known as corticobasal degeneration (corticobasal degeneration, CBD). It is a rare disease with symptoms similar to Parkinson's disease, but current treatments do not alleviate the condition.
It is reported that Zheng Peipei chose to donate her brain to the Brain Support Network (BSN) for medical research .
At the end of 2015, before she was diagnosed with the disease, Zheng Peipei said in an interview with the media: "I once told my children that after I leave, my ashes will be scattered in the Huangpu River. But because of the past two years, I have decided to The body will be donated to the University of Hong Kong. According to tradition, after the research is completed, the ashes will be scattered on the campus of the University of Hong Kong, so they may not be scattered in the Huangpu River, but I have always been proud to be a Shanghainese ."
cbd≠Parkinson’s disease!
The incidence rate is less than 1 per 100,000 people every year
Professor Yu Jintai of the Department of Neurology, Huashan Hospital Affiliated to Fudan University, pointed out that CBD is different from Parkinson's disease. "The pathology of the two is different. The former belongs to tau protein abnormality, while Parkinson's disease Involving alpha-synuclein. cbd progresses faster than Parkinson’s disease, and there is currently no specific drug. ”
Data shows that CBD is an extremely rare disease, with an incidence rate of less than 1 per 100,000 people per year. The general age of onset is 60 to 80 years old, with an average age of 63 years. The symptoms are subtle when the disease first occurs, and it is often misdiagnosed as Parkinson's disease or other degenerative diseases. The main clinical manifestations of are the gradually increasing asymmetric myotonia and functional loss of , accompanied by symptoms such as limb stiffness, dystonia, and apraxia. Over time, some patients also suffer from cognitive impairment, behavioral changes, and loss of speech.
Its causes mainly include three aspects:
➤ Genetic factors: Some CBD patients have a family genetic history.
➤ Environmental factors: Exposure to certain environmental toxins (such as pesticides, herbicides, trichlorethylene, etc.) may increase the risk of CBD.
➤ Age factor: As age increases, the functions of various organs in the body gradually deteriorate, and the levels of neurotransmitters such as dopamine in the body decrease, which may induce or accelerate the occurrence of CBD. How to identify
cbd in the early stage? How to intervene?
Experts from Shanghai Ruijin Hospital
recently explained in detail
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How to identify it early?
▶ Motor symptoms:
▶ Advanced cortical symptoms:
1. Apraxia : Apraxia of the affected limb is one of its core symptoms. Ideomotor apraxia is the most common type (patients lose the ability to rely on semantic memory to complete actions, which is manifested by the inability to complete complex actions or imitate actions according to instructions, but the patient knows how to do it, can say it, and can complete related actions spontaneously.
2. Alien limb : It manifests as complex unconscious body movements, or the feeling that the limb is not a part of oneself and has its own will, or it may only manifest as simple uncontrolled elevation of the limb.
3. Cortical sensory disorder. : Manifested as numbness or tingling, impaired joint position sense, two-point discrimination, and entity sensation, and visual neglect may also occur
4. Speech disorder : Manifested as primary progressive aphasia, including progressive non-fluency. Sexual aphasia is the most common type. CBD aphasia can develop into mutism. Speech apraxia can occur alone or simultaneously with aphasia.
5. Cognitive impairment and psychiatric symptoms : Amnestic cognitive impairment can occur, often leading to misdiagnosis of Alzheimer's disease. Psychiatric symptoms often manifest as apathy, depression, or frontal lobe behavioral disorders (personality changes, abnormal behavior, irritability, impulse control disorders, hypersexuality), and rarely visual hallucinations.
In addition, about 37% of CBD patients have difficulty with horizontal scanning in the early stage, and 63% of patients develop supranuclear ophthalmoplegia during the course of the disease, but it often appears in the late stage of the disease. About 50% of CBD patients are accompanied by active or hyperactive tendon reflexes.
Early intervention to reduce risk
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Source: Xinmin Evening News Comprehensive Shanghai Ruijin Hospital
