Zheng Peipei, a screen "heroine" who once starred as Madame Hua in "Tang Bohu Spots Autumn Fragrance" and Grandma Ling'er in "Legend of Sword and Fairy", passed away on July 17, local time in the United States at the age of 78.
Zheng Peipei
According to media reports, in 2019, Zheng Peipei was diagnosed with neurodegenerative atypical parkinsonism, whose informal name is corticobasal ganglia degeneration (cbd). It is a rare disease with symptoms similar to Parkinson's disease, but current treatments do not provide relief. She chose to donate her brain to the Brain Support Network (BSN) for medical research.
While remembering Ms. Zheng Peipei, you may have questions, why is the "Parkinson's disease" we often hear about still a rare disease? In this regard, Wang Gang, director of the Department of Neurology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, explained.
According to data, CBD was first reported by Rebeiz et al. from the neuropathology team of Massachusetts General Hospital in the United States in 1967. The name of the disease comes from the pathological abnormalities of different anatomical structures of the brain (cortex and basal ganglia), with asymmetric frontoparietal cortex and It is a tau protein disease based on basal ganglia lesions.
Wang Gang said that according to international reports, the annual incidence rate of CBD is only 0.62-0.92/100,000. Our country currently lacks corresponding epidemiological data, and it belongs to a type of Parkinson's superposition syndrome.
From a clinical point of view, the age of onset of CBD is generally 60-80 years old, and it is a neurodegenerative disease that commonly occurs in middle-aged and elderly people. Its onset is insidious, and its motor symptoms mainly include myotonia, gait instability, dystonia, and myoclonus characterized by progressive, asymmetric onset of levodopa resistance. It can also affect higher-level cortical functions, causing Abnormalities such as limb apraxia and cognitive impairment.
"Recently, the Parkinson's disease and related movement disorders multidisciplinary outpatient clinic (mdt) team of Renji Hospital diagnosed a similar patient with CBD and conducted individualized symptomatic treatment intervention." Wang Gang said that in fact, corticobasal degeneration The onset is insidious and the clinical manifestations are diverse, making early diagnosis a great challenge. “Corticobasal degeneration can manifest as Parkinson’s disease-like symptoms or Alzheimer’s disease-like symptoms, and the final pathological type can be either corticobasal ganglia degeneration or atypical Alzheimer’s disease. Alzheimer's disease, which manifests as corticobasal ganglia syndrome, is quite challenging for clinicians and is difficult to identify and diagnose. "
" With the advancement of detection methods, cerebrospinal fluid examination, PET imaging, and genes have been combined in a timely manner. "Auxiliary examinations such as analysis may help with early diagnosis and individualized treatment." Wang Gang further said that although there is still a lack of effective means to cure corticobasal degeneration, early detection can clarify the pathological type of the disease and focus on symptomatic treatment. Drugs and non-drug treatments, including physical therapy, speech therapy, neuropsychological therapy, etc., can also delay the development of the disease and improve the quality of life. At the same time, some new research methods are being tested in clinical trials .
Where can patients with suspected CBD go for treatment? In this regard, Wang Gang introduced that for CBD treatment, the movement disorder or cognitive impairment multidisciplinary (mdt) clinic or specialized disease clinic of a comprehensive tertiary hospital is preferred.
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