Blue Whale Finance Tu Jun
htmlOn the afternoon of February 4, a talk show actor posted on a certain platform that he was suspected of committing suicide, which attracted the attention of netizens; he was later found and his life was not in danger. However, later one of his responses once again sparked heated discussion on the Internet. He said, "Don't worry, everyone, I'm fine. I found that drinking cephalosporin can't kill you at all. Apart from a little stomach discomfort, there's nothing wrong with it."Affiliated with Tongji University Song Danqi, the pharmacist in charge of the Pharmacy Department of Tongji Hospital, reminds everyone not to be misled. "Pair cephalosporin with wine, just go" is not a joke. And not just cephalosporins, many drugs cannot be taken at the same time as alcohol to avoid "disulfiram-like reactions".
Song Danqi explained that the scientific name of alcohol is ethanol. Ethanol is mainly metabolized by the liver in the human body. Through the action of alcohol dehydrogenase, acetaldehyde is generated. Acetaldehyde is converted into acetic acid through the action of acetaldehyde dehydrogenase, and acetic acid is decomposed again into Hydrate carbon dioxide and excrete it from the body. This process is successfully completed, and alcohol is completely metabolized and excreted from the human body. In this process, alcohol dehydrogenase and acetaldehyde dehydrogenase play a major role.
The content of alcohol dehydrogenase in the human body is almost the same for everyone, but the content of acetaldehyde dehydrogenase varies greatly. Once you drink too much, these two enzymes cannot be decomposed in time, and you will become drunk. Condition.
Disulfiram-like reaction, also known as disulfiram-like reaction, refers to disulfiram or drugs containing methylthiotetrazole group that inhibits liver acetaldehyde dehydrogenase and hinders alcohol metabolism. Even a small amount of drinking can cause acetaldehyde poisoning. Reactions in mild cases may include weakness, dizziness, drowsiness, hallucinations, body flushing, headache, nausea, vomiting, and drop in blood pressure. In severe cases, severe reactions may include respiratory depression, collapse, convulsions, cardiac dysfunction, and even anaphylactic shock. life.
What drugs can cause disulfiram-like reactions?
Song Danqi pointed out that they mainly include the following types: first, cephalosporins, among which cefoperazone has been reported to cause disulfiram-like reactions more often and is relatively sensitive; second, nitroimidazole, such as metronidazole , tinidazole, ornidazole, etc.; third, other antibacterials, such as furazolidone, chloramphenicol, ketoconazole, etc.
In addition, there are many drugs such as: cold medicines (mostly containing acetaminophen, also known as paracetamol), sedative-hypnotics (diazepam, clonazepam, barbiturates, etc.), antihypertensive drugs ( Reserpine, captopril, nifedipine, etc.), hypoglycemic drugs (tolbutamide, glyburide, metformin, insulin, etc.), anti-allergic drugs (diphenhydramine, chlorpheniramine), etc. If you drink alcohol after taking the medicine, facial flushing, conjunctival congestion, blurred vision, severe pulsation of blood vessels in the head and neck or pulsating headache, dizziness, nausea, vomiting, sweating, dry mouth, chest pain, myocardial infarction, and acute heart failure may occur. , dyspnea, acute liver injury, drowsiness, confusion, coma, hypoglycemic reaction, convulsions, shock and death, etc.
Therefore, pharmacists suggest: "Spring Festival" is approaching. While celebrating the festival and sipping fine wines, you need to pay attention - "drink without taking medicine, and take medicine without drinking."
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